Anti-FEZ2 Antibody (C15-1317-554)

General description

Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C. elegans UNC-76. In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues. FEZ2 interacts with protein kinase C (PKC)-zeta substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-zeta, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC-zeta in a tissue non-specific manner. FEZ2 can interact with FEZ1 through its c-terminal regions and especially its coiled-coil region. At least two isoforms of FEZ2 are known to exist.

Immunogen

KLH-conjugated linear peptide corresponding to human FEZ2.

Application

Detect the FEZ2 protein using this Anti-FEZ2 validated for use in WB & IF.

Immunofluorescence Analysis: 5 µg/mLfrom a representative lot detected FEZ2 in human brain tissue.

Research Category
Neuroscience

Neuroscience

Research Sub Category
Developmental Neuroscience

Neuroregenerative Medicine

Quality

Evaluated by Western Blot in 3T3 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected FEZ2 in 15 µg of 3T3 cell lysate.

Target description

~38/50 kDa observed. An uncharacterized band may appear at ~48 kDa in some lysates.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
3T3 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human, mouse. technique(s): immunofluorescence: suitable, western blot: suitable. isotype: IgG. UniProt accession no.: Q9UHY8. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... FEZ2(9637). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.