ANTI-FEZF2 ANTIBODY (C15-1317-585)

General description

Fezf2 is a transcriptional repressor protein. It is required for the specification of corticospinal motor neurons and other subcerebral projection neurons. FeZf2 also plays a role in the layer and subcortical specific patterning of the subcortical projections and axonal fasciculations that develop in the brain. Fezf2 also controls the development of the dendritic arborization and spines of the large layer V pyramidal neurons. Thus biological processes involving Fezf2 include neuronal patterning, differentiation, neurogenesis, axon guidance, fasciculation, cortex development, anterior/posterior patterning, dendrite development, and locomotory behavior, and it was recently identified as a multipotent progenitor marker for neocortical projection neurons, astrocytes, and oligodendrocytes.

Immunogen

Epitope: Engrailed homology 1 repressor domain

KLH-conjugated linear peptide corresponding to the Engrailed homology 1 repressor domain of human Fezf2.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Fezf2 in rat spinal cord tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-Fezf2 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Fezf2.

Quality

Evaluated by Western Blotting in mouse E13-14 brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Fezf2 in 10 µg of mouse E13-14 brain tissue lysate.

Target description

~50 kDa observed

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: rat, human, mouse. species reactivity (predicted by homology): bovine (based on 100% sequence homology). technique(s): immunohistochemistry: suitable (paraffin), western blot: suitable. NCBI accession no.: NP_060478. UniProt accession no.: Q8TBJ5. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... FEZF2(55079). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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