General description
Formyl peptide receptors (FPRs) are G protein coupled receptors critical for our immune response and the cellular activation and or suppression of immune cell activities. N-formyl peptides are produced by the degradation of either bacteria or host cells and serve as chemoattractant agents for white blood cells. There are three known formyl peptide receptors, FPR1, FPR2, and FPR3 all appear to have similar functions. Binding of N-formyl peptides activates neutrophils via the phosphatidylinositol-calcium second messenger system. In some cases binding leads to a down regulation of immune signals such as in the down regulation observed against the proinflammatory signaling agent leukotriene B4. Interestingly, FPRs also have endogenous ligands which appear to function in a developmental fashion and not directly as an immune function. For instance, FPR2’s endogenous ligand is a peptide named Cathelin-related antimicrobial peptide (CRAMP) which is critical for proper dendritic cell maturation. FRP2 is abundantly expressed in the lung, spleen and testis neutrophils. Because of their role in the immune cell activation, FPRs are also being investigated as possible targets for modulating immune caused diseases such as arthritis.
Immunogen
Epitope: extracellular domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human FPR2.
Application
Anti-FPR2 Antibody | ABF118 is an antibody against FPR2 Antibody for use in Western Blotting, Flow Cytometry.
Flow Cytometry Analysis: 1.0 µg of this antibody detected FPR2 in HL-60 cells.
Research Category
Inflammation & Immunology
Quality
Evaluated by Western Blotting in HL-60 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected FPR2 in 10 µg of HL-60 cell lysate.
Target description
~45 kDa observed. The calculated molecular weight of this protein is 39 kDa, but can be observed at ~45 kDa due to high glycosylation.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human. technique(s): flow cytometry: suitable, western blot: suitable. NCBI accession no.: NP_001453. UniProt accession no.: P25090. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... FPR2(2358). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
More Information: https://cenmed.com/shipping-returns
- UPC:
- 51181912
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- ABF118
- Temperature Control Device:
- Yes
