ANTI -GABA (A) RECEPTOR (ALPHA6 SUBUNIT) DEVELOPED IN RABBIT AFFINITY ISOLATED ANTIBODY

General description

GABA_A and GABA_B receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.

Immunogen

peptide corresponding to amino acids 20-37 of rat GABA(A) α6. This sequence is identical in mouse and shares 17 of 19 residues in human.

Application

Anti-GABA_A Receptor (α 6 subunit) antibody produced in rabbit is suitable for the immunofluorescent detection of GABA_A receptor α 6 in cerebella of mice. It is suitable for immunoblotting at a working dilution of 1:200 using rat brain membranes.

Biochem/physiol Actions

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABA_A and GABA_B. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. Mutations in the gene may be responsible for the pathogenesis of childhood absence epilepsy (CAE). Polymorphism in this gene is also related to attenuation in hormonal and blood pressure responses under certain psychological stress.

Target description

Anti-GABA(A) Receptor (α6 subunit) specifically recognizes the GABA(A) receptor α6 subunit protein and may be used for the detection of the GABA(A) receptor α6 subunit protein. The inhibitory neurotransmitter GABA (α-aminobutyricacid

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Disclaimer

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