General description
The γ-glutamyltransferase (GGT) enzyme is located in the plasma membrane, with its catalytic site exposed to the extracellular space. It is broadly expressed with most abundant presence in kidney and liver. The gene GGT6 is mapped to human chromosome 17p13.2 and it encodes an isozyme of γ-glutamyltransferase.
Immunogen
Gamma-glutamyltransferase 6 Precursor recombinant protein epitope signature tag (PrEST)
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Biochem/physiol Actions
The gene GGT6 (γ-glutamyltransferase 6) encodes a member of the γ-glutamyltransferase family of proteins. The glycoprotein GGT catalyzes the extracellular catabolism of glutathione (GSH, γ-glutamyl-cisteinyl-glycine), the crucial thiol intracellular antioxidant compound present in mammalian cells, into glutamic acid and cysteinylglycine. It also functions as a transpeptidase, catalyzing the transfer of the γ-glutamyl moiety to acceptor amino acids. These amino acids assimilate and get reutilized by the cells for GSH synthesis. In the presence of iron or other transition metals, GGT generates reactive oxygen species. This GGT-mediated oxidative stress may be involved in inducing lipid oxidation, oxidation of protein thiols, and activation of certain transcription factors.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST75774.
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Legal Information
Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC
- UPC:
- 41116127
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- HPA023362-100UL
