General description

Glucose transporter 1 (GLUT1, SLC2A1) belongs to the family of glucose transporters (GLUTs). It is localized to the membrane and is highly expressed in the brain and spinal cord, with a relative high density in the cerebellum. The vascular form of GLUT1 is mainly localized in endothelial cells of blood vessels.

Immunogen

peptide corresponding to a sequence at the C-terminus of human GLUT1, conjugated to KLH. The corresponding sequence is identical in rat and mouse GLUT1.

Application

Anti-GLUT1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

GLUT1 is the main glucose transporter in the blood-brain barrier (BBB), which regulates basal glucose levels. Increased expression of GLUT1 is associated with cell growth and in malignant transformation.

Physical form

solution in 0.01 M phosÂphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

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