ANTI-N-METHYL-D-ASPARTATE R2B GLUTAMATE RECEPTOR

General description

Glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit 2B (GRIN2B) codes for N-methyl D-aspartate receptor subtype 2B (GluN2B). It is an important constituent of the N-methyl D-aspartate receptor protein. GRIN2B gene is located on human chromosome 12p13.1.

Immunogen

C-terminal portion of NR2B (amino acids 984-1104).

Application

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody is suitable for use in immunohistochemistry (1:1,000 dilution, using frozen sections), immunoprecipitation (3 μL using 200 μg of rat brain), and indirect ELISA. The antibody may also be used for western blot (1 μg/mL using (35S)-Protein A) and immunoblot (180 kDa).

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit 2B (GRIN2B) plays a key role in synaptic plasticity, language acquisition, neural pattern formation and short-term memory. Mutations on GRIN2B gene results in Parkinson′s disease, schizophrenia, bipolar disorder, Alzheimer′s disease and obsessive-compulsive disorder.

The functional N-Methyl-D-Aspartate (NMDA) receptor complex consists of a NMDAR1 (NR1) subunit and atleast one NMDAR2 subunit ranging from NR2A-NR2D. These receptor complexes have been implicated in cochlear functions and neuronal plasticity. The C-terminal end of NR2B receptor may regulate synaptic localization.

Physical form

Lyophilized from ammonium bicarbonate (5 mM).

Disclaimer

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