General description
GREB1, also known as gene regulated in breast cancer protein 1 is shown to be involved in the proliferation of breast cancer cells, controlled by estrogen. GREB1 has the potential to be a clinical marker for response to endocrine therapy and a therapeutic target. GREB1 also may be the regulator for prostate cancer.
Immunogen
Recombinant protein corresponding to human GREB1.
Application
Immunohistochemistry Analysis: 1:600 dilution from a previous lot detected GREB1 in prostate tissue.
Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IP. (Hnatyszyn, H., et al. 2009). Breast Cancer Res Treat
DOI 10.1007/s10549-009-0584-x.)
Research Category
Signaling
Apoptosis & Cancer
Research Sub Category
Hormones & Receptors
This Anti-GREB1 Antibody, clone GREB1Ab is validated for use in WB, IH, IC for the detection of GREB1.
Quality
Evaluated by Western Blot in MCF-7 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected GREB1 on 10 µg of MCF-7 cell lysate.
Target description
~ 216 kDa observed. Uncharacterized bands may be observed in some lysates.
Physical form
Format: Purified
Protein G
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
MCF-7 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
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- UPC:
- 41116012
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- MABS62
- Temperature Control Device:
- Yes
