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ANTI-HDAC3 ANTIBODY CLONE 3G6

Sigma Aldrich

Catalog No.
C15-1616-318
Manufacturer No.
05-813
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
EA
Price: $1,056.31
List Price: $1,173.68

General description Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.

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General description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene.

Specificity

HDAC3

Predicted to cross-react with rat and chicken based on sequence homology

Immunogen

peptide (NEFYDGDHDNDKESDVEI) corresponding to amino acids 411-428 of human HDAC3

Application

Anti-HDAC3 Antibody, clone 3G6 is a Mouse Monoclonal Antibody for detection of HDAC3 also known as histone deacetylase 3 & has been tested in IP, WB, ICC.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Histones

Quality

routinely evaluated by immunoprecipitation/HDAC

Target description

49-53kDa

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%.

Format: Purified

Protein G Purified

Storage and Stability

2 years at -20°C

Analysis Note

Control
HL-60 cell lysate

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

UPC:
51202407
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
05-813
Product Size:
813

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