ANTI-HEY1 ANTI-HEY1 (C005B-098558)

General description

Hairy/enhancer-of-split related with YRPW motif 1 (HEY1, HESR1, HERP2, HRT1, CHF2), a basic helix-loop-helix (bHLH)-type transcription factor/repressor, is a downstream effector of Notch and c-Jun signaling. HEY1/HESR1 is involved in the regulation of cardiovascular, skeletal muscle, osteoblast, osteoclast, chondrocyte and neural development. HEY1/HESR1 is a repressor of myoblast differentiation/myogenesis and human dopamine transporter (DAT1) gene expression.

Specificity

Rabbit polyclonal anti-HEY1/HESR1 antibody reacts with human, mouse, rat, bovine, and canine Hairy/enhancer-of-split related with YRPW motif 1 transcription factors.

Immunogen

Synthetic peptide directed towards the C-terminal region of Human HEY1

Application

Rabbit polyclonal anti-HEY1/HESR1 antibody is used to tag Hairy/enhancer-of-split related with YRPW motif 1 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of Hairy/enhancer-of-split related with YRPW motif 1 in cardiovascular, skeletal muscle, osteoblast, osteoclast, chondrocyte and neural development.

Biochem/physiol Actions

Hairy/enhancer of split-related proteins, such as HEY1, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates.

Sequence

Synthetic peptide located within the following region: PQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSFGPVLPVVTS

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.