General description
Homeobox protein CDX-2 (UniProt Q99626; also known as Caudal-type homeobox protein 2, Caudal type homeobox transcription factor 2, CDX-3) is encoded by the CDX2 (also known as CDX3, CDX2/AS) gene (Gene ID 1045) in human. CDX-2 is a transcription factor that plays an important role during embryonic development, where it determines intestinal identity in the presumptive gut endoderm. CDX-2 is also required for maintenance of intestinal identity in the intestinal epithelium throughout adulthood. Mitogen-activated protein kinases (MAPK) are reported to modulate CDX2 transcriptional activity and half-life via phosphorylation. Reduction of CDX2 expression facilitates tumor progression in murine models of colorectal cancer (CRC) and decreased CDX2 expression level in CRC correlates with poor prognosis in human.
Immunogen
Epitope: Internal
GST-tagged recombinant protein corresponding to human Homeobox protein CDX-2.
Application
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Homeobox protein CDX-2 in human colon and human colorectal cancer tissue.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Nuclear Receptors
This Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Homeobox protein CDX-2.
Quality
Evaluated by Western Blotting in human colorectal adenocarcinoma DLD-1 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Homeobox protein CDX-2 in 10 µg of human colorectal adenocarcinoma DLD-1 cell lysate.
Target description
~35/39 kDa observed. Target band often appears as a doublet due to posttranslational modifications (phosphorylations & polyubiquitinations).
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
More Information: https://cenmed.com/shipping-returns
- UPC:
- 51172302
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- MABE988
- Temperature Control Device:
- Yes
