General description
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human IκBα (NP_065390.1).
Physical form
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Shipping Information:
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- UPC:
- 51201571
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SAB5700926-100UL
- Temperature Control Device:
- Yes
