ANTI-INTEGRIN BETA1 ANTIBODY PHOSPHO-SPECIFIC [THR788/THR789] (C005B-239765)

General description

Integrin beta1 is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.

Specificity

The antibody detects a 130 kDa protein of integrin beta1 receptor.

Immunogen

Epitope: pT788/789

Phosphorylated synthetic peptide corresponding to amino acid residues surrounding and including threonine 788/789 of the human beta1 integrin. The immunogen sequence is 100% identical in mouse, rat and chicken integrin beta1.

Application

Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789] is an antibody against Integrin β1 for use in WB.

Research Category
Cell Structure

Research Sub Category
Integrins

Western Blot: 1:1000.

Optimal working dilutions must be determined by end user.

Linkage

Replaces: 04-1109

Physical form

Antibody is cross-adsorbed to nonphospho-peptide corresponding to the site of phosphorylation then affinity purified using phosphorylated integrin beta1 receptor (Thr788/789) peptide. Antibody is supplied in Dulbecco′s phosphate-buffered saline (without Mg²⁺ or Ca²⁺), pH 7.3, 50% glycerol and 1 mg/mL BSA.

ImmunoAffinity Purified

Storage and Stability

Maintain at -20°C for up to one year from date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human. manufacturer/tradename: Chemicon^®. . technique(s): western blot: suitable. NCBI accession no.: NM_002211.2, NM_033666.1, NM_033667.1, NM_033668.1, NM_033669.1, NM_133376.1. UniProt accession no.: P05556. shipped in: dry ice. target post-translational modification: phosphorylation (pThr788/pThr789). Gene Information: human ... ITGB1(3688). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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