General description
Interleukin-23 subunit alpha (IL-23A or IL-23, p19 subunit) is a subunit of heterodimeric cytokine IL-23, which also contains the p40 subunit of interleukin 12 (IL-12B). The receptor of IL-23 is formed by the beta 1 subunit of IL-12 (IL-12RB1) and an IL-23 specific subunit, IL-23R. IL-23 activates the transcription activator STAT4, and stimulates the production of interferon-gamma. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation.
Specificity
Antibody recognizes the mature chain of IL-23 subunit alpha.
Immunogen
Epitope: Mature chain of IL-23, subunit alpha.
KLH-conjugated linear peptide corresponding to the mature chain of human IL-23 subunit alpha.
Application
Detect Interleukin 23 alpha (IL-23A) using this Anti-Interleukin 23 alpha (IL-23A) Antibody validated for use in WB, FC.
Flow Cytometry Analysis: 1 µg from a previous lot detected IL-23 alpha in human PBMC′s.
Quality
Evaluated by Western Blot in 3T3/A31 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected IL-23 alpha in 10 µg of 3T3/A31 cell lysate.
Target description
UniProtKB/Swiss-Prot entry Q9NPF7 lists a molecular weight of 20.730 kDa In some lysates tested, non-specific bands are observed at around 40 kDa and around 55 kDa
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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- UPC:
- 51342709
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 06-1079
- Temperature Control Device:
- Yes
