Immunogen

Immunogen Sequence: GI # 4504747, sequence 1015-1051

Recombinant integrin α 3 isoform a

Application

Anti-ITGA3 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Integrin α-3 is a protein encoded by the ITGA3 gene in humans and is a member of the integrin family of cell adhesion receptors. It is a transmembrane integrin receptor subunit for various laminin isoforms that mediates signals between the cells and their microenvironment. ITGA3 plays an important role in the maintenance of tissue integrity. It may function as a receptor for fibronectin, laminin, and collagen. ITGA3 plays a central role in the interplay of cells, morphogens and ECM and is required for proper nephrogenesis. It acts as a potential marker protein for cells undergoing enhanced Epithelial-mesenchymal transition (EMT) and for cancer cells with aggressive phenotypes.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.