General description
LMX-1 is a transcription factor that belongs to the LIM-homeodomain (LIM-HD) transcription factor family. It is induced within the ventral midbrain as a response to early signaling. LMX-1 is a necessary component for the development of the roof plate and for CNS dorsal cell date specification and the development of vertebrae. It is Expressed in roof plate, an organizational locus found in the dorsal CNS that functions to moderate the differentiation and specification of adjacent neurons through the secretion of signaling molecules such as WNT and BMP. Recent studies have indicated that LMX-1 has high potential for stimulating the production of mesencephalic dopamine neurons(mesDA) for the therapeutic treatment Parkinson disease, a condition characterized by dopaminergic neurotransmission decline resulting from the progression of mesDA neuronal degeneration within the substantia nigra pars compacta (SN).
Specificity
This antibody recognizes LMX-1.
Immunogen
Epitope: C-terminus
GST-tagged recombinant protein corresponding to the C-terminus of hamster LMX-1.
Application
Anti-LMX-1 Antibody is an antibody against LMX-1 for use in WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Neuronal & Glial Markers
Quality
Evaluated by Western Blot in mouse testis tissue lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected LMX-1 on 10 µg of mouse testis tissue lysate.
Target description
~50 kDa observed.
Physical form
Unpurified
Unpurified rabbit polyclonal serum containing 0.05% sodium azide.
Storage and Stability
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
Mouse testis tissue lysate
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source: rabbit. Quality Level: 100. antibody form: serum. antibody product type: primary antibodies. clone: polyclonal. species reactivity: mouse, rat. species reactivity (predicted by homology): hamster (based on 100% sequence homology). technique(s): western blot: suitable. isotype: IgG. GenBank®. accession no.: AAB62320. UniProt accession no.: Q04650. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: hamster ... Lmx1A(101839559)mouse ... Lmx1A(110648)
rat ... Lmx1A(289201). Storage Class Code: 10 - Combustible liquids. WGK: WGK 1.
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- UPC:
- 51142005
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- AB10533
- Temperature Control Device:
- Yes
