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ANTI-EDG-2 (ENDOTHELIAL CELL DIFFERENTIATION GENE 2) C-TERMINAL

Sigma Aldrich

Catalog No.
C15-1356-841
Manufacturer No.
E5017-.1MG
Manufacturer Name
Sigma-Aldrich
Quantity
0.1
Unit of Measure
MG
Price: $2,103.90
List Price: $2,337.66

Immunogen synthetic peptide corresponding to amino acids 328-344 of human EDG-2/LPA 1 . Application Anti-LPA 1 , C-Terminal antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat brain microsomal

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Immunogen

synthetic peptide corresponding to amino acids 328-344 of human EDG-2/LPA1.

Application

Anti-LPA1, C-Terminal antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat brain microsomal fraction.

Biochem/physiol Actions

Lysophosphatidic acid receptor 1 (LPA1) is a protein encoded by the LPAR1 gene in humans. It is constitutively localized in the nucleus of mammalian cells and may be involved in regulating intranuclear protein phosphorylation and signalling. LPA1 is differentially expressed in androgen-insensitive and LPA-responsive cells. It is not expressed in androgen-dependent and LPA-resistant cells.Its expression is significantly higher in the cancer compared with the benign tissues and may possibly act as a drug target to interfere with progression of prostate cancer. LPA1 helps in promoting cell proliferation, survival and migration by acting on cognate G protein-coupled receptors.

Physical form

Solution in PBS with 0.08% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

UPC:
12352203
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
E5017-.1MG

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