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ANTI-LRP6 (C-TERM H1497) ANTIBODY PRODUCED IN RABBIT

Sigma Aldrich

Catalog No.
C15-1755-665
Manufacturer No.
SAB1300742-100UG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
EA
Price: $825.16
List Price: $916.84

General description Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid

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General description

Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration. Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes. All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family.

Immunogen

LRP6 (NP_002327, )
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP6.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

UPC:
41116127
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
SAB1300742-100UG
Product Size:
100/µG

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