Anti-LTBP-3 Antibody (C15-1318-045)

General description

LTBP3 is a critical secreted protein that is part of the multi-protein complex that controls the action and release of the powerful developmental, immune, and signaling factor TGF-beta. LTBP3’s specific role appears to be in regulating the activation of the TGFB1 precursor complex. The removal of LTBP3 is essential for the activation of the complex. LTBP3 is expressed in many tissues including heart, skeletal muscle, prostate, testis, small intestine, ovary, pancreas, and liver. Recent research also demonstrates that LTBP3 plays important roles in many human carcinomas including breast, hepatic, and mesothelioma.

Immunogen

KLH-conjugated linear peptide corresponding to human LTBP-3.

Application

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

This Anti-LTBP-3 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of LTBP-3.

Western Blotting Analysis: 2.0 µg/mL from a representative lot detected LTBP-3 in 10 µg of U2OS conditioned media.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LTBP-3 in human prostate tissue.

Quality

Evaluated by Western Blotting in mouse testis tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected LTBP-3 in 10 µg of mouse testis tissue lysate.

Target description

~240 kDa observed. The calculated molecular weight of this protein is 139 kDa, but can be observed at ~240 kDa due to high glycosylation.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human, mouse. technique(s): immunohistochemistry: suitable, western blot: suitable. NCBI accession no.: NP_001123616. UniProt accession no.: Q9NS15. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... LTBP3(4054). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.