ANTI-LTBP1 HINGE REGION (RABBIT POLYCLONAL) (C005B-241700)

General description

Latent-transforming growth factor beta-binding protein 1 (LTBP-1) is also called Transforming growth factor beta-1-binding protein 1 (TGF-beta1-BP-1). A large latent complex of TGFB1 from platelets is composed of the TGFB1 molecule non-covalently associated with a disulfide-bonded complex of a dimer of the N-terminal propeptide of the TGFB1 precursor and LTBP1. LTBP1 does not bind directly to active TGFB1 only to proforms. LTBP1 appears to be involved in the secretion of TGFB1 to sites at which it is stored or activated, and it is critical in controlling the action of TGFB1. LTBP1 may also play a role in extracellular matrix building and calcium binding mediated signaling surrounding TGFB1 activated signaling pathways. Also, because of its critical role in TGFB1 metabolism, LTBP1 is an important player in many developmental processes including embryo implantation and growth. LTBP1 is also a player in at least two distinct breast cancer metastasis signatures and has both a long and short isoform that work to establish and maintain the spatial restriction of TGFbeta bioavailability during development of many tissues including mammary development.

Immunogen

Linear peptide corresponding to rat LTBP1 hinge region.

Application

Immunocytochemistry Analysis: A representative lot detected LTBP1 hinge region in rat FRC and MG63 cells (Dallas, S., et al. (2000). Journal of Bone and Mineral. 15(1):68-81).

This Anti-LTBP1 antibody is validated for use in WB, IC for the detection of LTBP1.

Quality

Evaluated by Western Blotting in NIH/3T3 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected LTBP1 hinge region in 10 µg of NIH/3T3 cell lysate.

Target description

~190 kDa observed. Uncharacterized band(s) may appear in some lysates.

Other Notes

Concentration: Please refer to lot specific datasheet.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: mouse, rat. technique(s): immunocytochemistry: suitable, western blot: suitable. NCBI accession no.: NP_067598. UniProt accession no.: Q00918. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: mouse ... Ltbp1(268977). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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