General description

Liver X receptor α and β (LXR-α/LXR-β) are members of LXRs that belong to the nuclear receptor superfamily. LXR-α is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity. The gene encoding this protein is localized on to human chromosome 11p11.2.

Immunogen

Peptide with sequence CRLQDKKLPPLLSEI from the internal region of the protein sequence according to NP_005684; NP_009052.

Biochem/physiol Actions

Liver X receptor α (LXR-α) has an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.

Features and Benefits

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Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.