Anti-MEF2D Antibody (C15-1315-971)

General description

Myocyte-specific enhancer factor 2D is a transcriptional activator belonging to the MEF2 family. MEF2D has two domains of interest; a MADS-box domain, and a Mef2-type DNA-binding domain specifically binding to 5′-YTA[AT]4TAR-3′, the MEF2 element, which is observed in several gene types such as growth factor, muscle-specific, and stress-induced genes. MEF2D regulates various cellular processes including those within cardiac and skeletal muscle development, neuronal survival and differentiation, as well as cell growth, apoptosis and survival. MEF2D, along with ERK5, plays a vital role in neuronal survival by regulating the anti-apoptotic molecule, bcl-w. There are 6 known isoforms of MEF2D resulting from alternative splicing.

Immunogen

KLH-conjugated linear peptide corresponding to human MEF2D.

Application

Anti-MEF2D Antibody is an antibody against MEF2D for use in WB, IH(P).

Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected MEF2D in normal human breast skin and inflammatory skin tissue.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Quality

Evaluated by Western Blot in L6 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected MEF2D on 10 µg of L6 cell lysate.

Target description

Observed at ~ 54 kDa

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
L6 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: rhesus macaque, rat, human, mouse, pig, horse. species reactivity (predicted by homology): equine (based on 100% sequence homology), porcine (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), canine (based on 100% sequence homology). technique(s): immunohistochemistry: suitable (paraffin), western blot: suitable. NCBI accession no.: NP_005911. UniProt accession no.: Q14814. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... MEF2D(4209). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.