ANTI-MGLUR4 ANTIBODY (C005B-239565)

General description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Specificity

Cat. # AB15097 recognizes mGluR4 (GRM4).

Reactivity with other species has not been determined.

Immunogen

Recombinant Protein.

Application

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

This Anti-mGluR4 Antibody is validated for use in WB for the detection of mGluR4.

Quality

Western Blot:
Mouse Brain Lysate.

Target description

~101 kDa

Physical form

Antigen Affinity Purified

Format: Purified

Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

Storage and Stability

Stable for 1 year at 2-8ºC from date of receipt.

Analysis Note

Control
Mouse Brain Lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. species reactivity: mouse, rat. technique(s): western blot: suitable. NCBI accession no.: NP_001013403.1. UniProt accession no.: Q68EF4. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: mouse ... Grm4(268934). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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