General description
MIB1 (Mindbomb homology 1) are E3 ubiquitin ligases. It is abundantly expressed in both embryos and adult tissues, whereas MIB2 is highly expressed in adult tissues.
Mindbomb homolog 1 (MIB1) is an ubiquitin ligase which possesses two substrate recognition domains, ankyrin repeats and an amino terminal zinc finger domain.
Immunogen
synthetic peptide corresponding to amino acids 924-939 of human MIB1, conjugated to KLH. The corresponding sequence is identical in rat and mouse.
Application
Anti-MIB1 (C-terminal) antibody produced in rabbit has been used in:immunofluorescence, immunoprecipitation , western blotting immunohistochemistry
Anti-MIB1 (N-terminal) antibody produced in rabbit has been used for immunofluorescence.
Biochem/physiol Actions
MIB1 is critical for mammalian development and cellular differentiation. It also plays a role in neuronal morphogenesis partially through physical interaction with cyclin-dependent kinase 5 (CDK5)/p35. Knockout of MIB1 in mice results in embryonic mortality with many defects observed in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis.
Mindbomb homolog 1 (MIB1) aids in the ubiquitination and internalization of Notch ligands such as the protein δ. It also acts as a positive regulator in the activation of nuclear factor-κB (NF-κB).
Physical form
Solution in 0.01 M phosphate buffered saline, pH7.4, containing 15 mM sodium azide.
Disclaimer
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- UPC:
- 51201812
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- M5948-100UL
- Temperature Control Device:
- Yes
