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ANTI-MINT-2 DEVELOPED IN RABBIT AFFINITY ISOLATED ANTIBODY

Catalog No.
C15-1891-060
Mfr. No.
M3319-200UL
Mfr. Name
Sigma-Aldrich
Qty/UOM
1
UOM
EA
Price: $1,068.40
List Price: $1,187.11

General description Munc-18-1 interacting protein 2 (Mint2), also called X11L, shares 50% homology with Mint1 and both are expressed exclusively in brain and bind Munc-18-1 with high affinity. It has N-terminal Munc-18-1-interacting domain (MID),

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General description

Munc-18-1 interacting protein 2 (Mint2), also called X11L, shares 50% homology with Mint1 and both are expressed exclusively in brain and bind Munc-18-1 with high affinity. It has N-terminal Munc-18-1-interacting domain (MID), a middle phosphotyrosine-binding (PTB) domain, and two C-terminal PDZ domain. It belongs to mammalian LIN-10 protein family. Mint 2 is present in neurons.

Immunogen

synthetic peptide corresponding to amino acids 1-18, located at the N-terminus of rat mint2, conjugated to KLH. This sequence is highly conserved (single amino acid substitution) in mouse mint2 and shows limited homology (66% identity) to human mint2. It does not share homology with the mint1 and mint3 isoforms.

Application

Anti-Mint2 antibody produced in rabbit has been used in:

  • immunoblotting
  • immunoprecipitation
  • immunostaining

Biochem/physiol Actions

Munc-18-1 interacting protein 2 (Mint2) participates in vesicle exocytosis. Mint 2 interacts with amyloid-β precursor protein (APP) and presenilins. It favors phosphorylation of β-amyloid precursor protein family members APP and Amyloid-like protein 2 (APLP2) in response to cellular stress, by facilitating c-Jun N-terminal kinase mediated phosphorylation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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UPC:
51314375
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
M3319-200UL
Temperature Control Device:
Yes

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