Anti-MORF4 Antibody (C15-1316-696)

General description

Mortality factor 4 (MORF4) is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes typically by acetylation of nucleosomal histones H4 and H2A. NuA4 complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, DNA repair and apoptosis. MORF4 is localized to the nucleus and has transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif. Additionally, MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.

Immunogen

KLH-conjugated linear peptide corresponding to human MORF4.

Application

Anti-MORF4 Antibody is a highly specific rabbit polyclonal antibody, that targets Mortality factor 4 & has been tested in western blotting, IHC & Immunofluorescence.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected MORF4 in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected MORF4 in HepG2 cells.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Quality

Evaluated by Western Blotting in K562 cell lysate

Western Blotting Analysis: 2 µg/mL of this antibody detected MORF4 in 15 µg of K562 cell lysate.

Target description

~33 kDa observed

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
K562 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human. technique(s): immunofluorescence: suitable, immunohistochemistry: suitable, western blot: suitable. UniProt accession no.: Q9UBU8. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... MORF4(10934). Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.