ANTI-MPPE1 (C15-1447-823)

General description

Metallophosphoesterase 1 (MPPE1) belongs to the dimetal-containing phosphoesterase family. It is located at the endoplasmic reticulum-exit site, endoplasmic reticulum-Golgi intermediate compartment and the cis-Golgi. The gene encoding this protein is present on chromosome 18p11.2. It contains a signal sequence of 45 residues at the amino-terminus, a metallo-phosphoesterase domain and a transmembrane domain at the carboxyl-terminus.

Immunogen

Metallophosphoesterase 1 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Metallophosphoesterase 1 (MPPE1) transports glycophosphatidyloinositol (GPI)-anchored proteins from the endoplasmic reticulum (ER) to the Golgi. This is done by recruiting and sorting them together with the p24 (a transmembrane protein) heteromeric complexes to the ER-exit site. MPPE1 also plays an important role in the lipid remodeling steps of GPI-anchor maturation. It removes the side-chain ethanolamine-phosphate (EtNP) from the second Mannose residue (Man2) of the GPI intermediate. This is one of the crucial steps for the transport of GPI-anchor proteins.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST70317.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

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