ANTI-MS4A3 (C15-1449-258)

General description

The gene MS4A3 (membrane-spanning 4-domains subfamily A member 3) is mapped to human chromosome 11q12.1. It belongs to the family of four-transmembrane proteins called as MS4A. MS4A3 is also referred to as HTm4 (hematopoietic-specific transmembrane protein 4).

Immunogen

Membrane-spanning 4-domains subfamily A member 3 recombinant protein epitope signature tag (PrEST)

Application

Anti-MS4A3 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

Biochem/physiol Actions

MS4A3 (membrane-spanning 4-domains subfamily A member 3) is a cell cycle regulator of the hematopoietic and tumor cell. It binds with the KAP (cyclin-dependent kinase-interacting phosphatase)-CDK2 (cyclin dependent kinase 2) complex and arrests cells in G0/G1 phase.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST72913.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.