ANTI-MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG) ANTIBODY

General description

Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG′s possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.

Specificity

May cross react with human and bovine based on sequence similarity.

Membane associated region of MOG [Myelin oligodendrocyte glycoprotein].

Immunogen

Epitope: The antibody binds to a discontinuous epitope present on the extracellular immunoglobulin V-like domain of MOG.

Rat cerebellar glycoproteins

Application

Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody is an antibody against Myelin Oligodendrocyte Glycoprotein (MOG) for use in FC, IC, IH & WB.

Research Category
Neuroscience

Research Sub Category
Neuronal & Glial Markers

Quality

Routinely evaluated by immunoblot.

Target description

28 kDa

Physical form

Format: Purified

Purified immunoglobulin

Purified in 0.1 M Tris-Glycine, 0.15 M NaCl, pH 7.4 and 0.05% Sodium Azide

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Analysis Note

Control
brain lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.