ANTI-NEUREXIN3 ANTIBODY (C15-1317-664)

General description

Neurexins are heavily glycosylated and processed neuronal transmembrane cell surface proteins likely involved in cell recognition and adhesion. (Missler, M., et al. (1998) 14(1):20-26) Antibody Anti-neurexin 3 alpha (ABN96) was made against a peptide immunogen corresponding to a stretch of amino acids in the extracellular domain of human neurexin 3 alpha (Uniprot Q9Y4C0). Although the theoretical full length of Neurexin 1alpha is 180 kDa, the protein detected in human brain lysates may show a band around 180 kDa and additional bands around 40-55 kDa as a possible result of the posttranslational processing previously reported.

Immunogen

KLH-conjugated linear peptide corresponding to human Neurexin-3.

Application

Detect Neurexin3 using this Anti-Neurexin3 Antibody validated for use in WB, IH.

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Neurexin-3 in normal mouse brain tissue.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Quality

Evaluated by Western Blot in PC12 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Neurexin-3 in 10 µg of PC12 cell lysate.

Target description

~180 kDa observed. UniProtKB/Swiss-Prot Q9Y4C0 (NRX3A_HUMAN) states 2 isoforms due to alternative promoter usage and alternative splicing at a molecular weight of ~181 kDa and ~117 kDa, with several beta isoforms at a molecular weight 70 kDa, 51 kDa, 47 kDa, and 44 kDa Additional bands may also be observed around 40-55 kDa as a possible result of the posttranslational processing.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
PC12 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human, mouse, rat. technique(s): immunohistochemistry: suitable, western blot: suitable. NCBI accession no.: NP_004787. UniProt accession no.: Q9Y4C0. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... NRXN3(9369). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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