ANTI-NOGO RECEPTOR ANTIBODY (C15-1315-726)

General description

Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord.

Specificity

Cat. # AB15138 recognizes the mature form of Nogo Receptor.

May react with human and primate based on sequence homology. Reactivity with other species has not been determined.

Immunogen

Epitope: Mature Form

Recombinant protein.

Application

Anti-Nogo Receptor Antibody detects level of Nogo Receptor & has been published & validated for use in WB, IH.

Non-Lot Specific Tested Application 1:
Immunohistochemistry: Working dilutions of 1:50-1:500 in rat brain and spinal cord (paraffin embedded)

Research Category
Neuroscience

Research Sub Category
Growth Cones & Axon Guidance

Quality

Routinely tested on mouse cerebellum lysate.
Lot Specific Tested Application 1: Western Blot

Target description

~50.9 kDa

Physical form

Format: Purified

Protein A purified

Purified in PBS with 0.1% NaN3

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Analysis Note

Control
Mouse cerebellum lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: purified antibody. antibody product type: primary antibodies. clone: polyclonal. species reactivity: mouse, human, rat. technique(s): immunohistochemistry: suitable, western blot: suitable. NCBI accession no.: NM_022982. UniProt accession no.: Q99PI8. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: mouse ... Rtn4R(65079). Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.