ANTI-OLIGODENDROCYTE TRANSCRIPTION FACTOR 2 (OLIG2) (GUINEA PIG POLYCLONAL) (C005B-240660)

General description

Oligodendrocyte transcription factor 2 (OLIG2), also known as Oligodendrocyte transcription factor 2 Oligo2, Class B basic helix-loop-helix protein 1 (bHLHb1), Class E basic helix-loop-helix protein 19 (bHLHe19), Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17, is encoded by the gene name OLIG2/ BHLHB1/ BHLHE19/ PRKCBP2/ RACK17. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Olig2 is an antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. The restricted expression of Olig2 in oligodendrocytes makes AB9610 an excellent marker of oligodendroglia and oligodendrogliomas in development and mature systems. Olig2 is expressed in the brain and oligodendrocytes. Olig2 is strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

Immunogen

Epitope: Unknown

KLH-conjugated linear peptide corresponding to mouse Oligodendrocyte transcription factor 2 (OLIG2).

Application

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Oligodendrocyte transcription factor 2 (OLIG2) in human cortical brain section tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-Oligodendrocyte transcription factor 2 (OLIG2 antibody is validated for use in WB, IH(P) for the detection of Oligodendrocyte transcription factor 2 (OLIG2.

Quality

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: A 1:1;000 dilution of this antibody detected Oligodendrocyte transcription factor 2 (OLIG2) in 10 µg of mouse brain tissue lysate.

Target description

~37 kDa observed

Physical form

Guinea pig polyclonal serum with 0.05% sodium azide.

Unpurified

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: guinea pig. Quality Level: 100. antibody form: serum. antibody product type: primary antibodies. clone: polyclonal. species reactivity: mouse, human. technique(s): immunohistochemistry: suitable (paraffin), western blot: suitable. NCBI accession no.: NP_058663. UniProt accession no.: Q9EQW6. shipped in: dry ice. target post-translational modification: unmodified. Storage Class Code: 10 - Combustible liquids. WGK: WGK 1.

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