General description
Purified mouse monoclonal antibody. Recognizes the ~50 kDa PAI-1 protein.
Recognizes the ~50 kDa PAI-1 protein.
This Anti-PAI-1 Mouse mAb (MA-33B8) is validated for use in Immunoblotting, Neutralization Studies for the detection of PAI-1.
Immunogen
Human
human tPA-PAI-1 complex
Application
Immunoblotting (10 µg/ml)
Neutralization Studies (see application references)
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
In 100 mM NaCl, 50 mM sodium phosphate buffer, pH 7.4.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Montes, R., et al. 2000. Thromb. Haemost.84, 65.
Verhamme, I., et al. 1999. J. Biol. Chem.274, 17511.
Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta1337, 257.
Rapidly inactivates PAI-1 (Plasminogen Activator Inhibitor-1) to the latent form. Like the native latent form, PAI-1 inactivated by antibody was protected from cleavage by elastase. Also shown to reduce renal fibrin deposits in a rabbit model of endotoxemia. Variables associated with assay conditions will dictate the proper working dilution.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
biological source: mouse. Quality Level: 100. antibody form: purified antibody. antibody product type: primary antibodies. clone: MA-33B8, monoclonal. Assay: ≥. 90% (SDS-PAGE). form: liquid. does not contain: preservative. species reactivity: rabbit, human. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, avoid repeated freeze/thaw cycles. isotype: IgG. shipped in: wet ice. storage temp.: −. 70°C. target post-translational modification: unmodified. Gene Information: human ... SERPINE1(5054). Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51202402
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 528215-100UG