ANTI-PARKIN ANTIBODY PRODUCED IN RABBIT (C15-1736-607)

General description

Anti-Parkin Antibody detects endogenous levels of total Parkin protein.

Parkin RBR E3 ubiquitin protein ligase (PARK2) is a putative tumor suppressor gene. It possesses an amino-terminal region containing the Ubl (ubiquitin like) domain and a carboxy-terminal region with four zinc coordinating domains. Parkin is a 465 amino acid protein, which is part of the ubiquitin-proteasome system that targets proteins for degradation. The gene encoding it is localized on human chromosome 6q25.2-q27.

Immunogen

The antiserum was produced against synthesized peptide derived from human Parkin.

Immunogen Range: 1-50

Application

Anti-Parkin antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

The expression of parkin RBR E3 ubiquitin protein ligase (PARK2) has been found to be altered in various malignancies. Parkin has a neuroprotective E3 ligase activity and polyubiquitylates proteins before degradation. Mutations in the gene encoding it have been linked to autosomal recessive juvenile parkinson (ARJP) disease.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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