ANTI-PHOSPHO-CD3 ZETA (PTYR142) ANTIBODY PRODUCED IN RABBIT AFFINITY ISOLATED ANTIBODY

General description

The TCR-CD3 multimeric complex is composed of TCRαβ, CD3γε and CD3δε and TCR‐ζ homodimer. The CD3γ, CD3δ and CD3ε, each contain one immunoreceptor tyrosine-based activation motif (ITAM), whereas the ζ chain contains three ITAMs.

Immunogen

synthetic phosphopeptide corresponding to residues surrounding Tyr¹⁴² of mouse CD3ζ, conjugated to KLH. The corresponding sequence is identical in human CD3ζ.

Application

Anti-phospho-CD3ζ (pTyr142) antibody produced in rabbit has been used in several immunochemical techniques including immunoblotting and immunoprecipitation.

Biochem/physiol Actions

Amongst the TCR subunits, the CD3 ζ chain plays a key role in regulating TCR assembly, transport, and cell surface expression. Down-regulation of TCR ζ chain expression associated with T cell dysfunction was described in various pathologies.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

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