General description

The neutrophil cytosolic factor 1 (NCF1), also known as p47phox gene, spanning 15kb with 11 exons, is mapped to human chromosome 7q11.23. The gene codes for a 390 amino acid protein, which is a novel component of the NADPH oxidase complex.

Immunogen

The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser345.

Immunogen Range: 311-360

Biochem/physiol Actions

Neutrophil cytosolic factor 1 (NCF1) stimulates the production of reactive oxygen species (ROS) under hyperoxic condition. The above process can be inhibited by the NCF1 inhibitor diphenylene iodonium (DPI) and apocynin. Mutation in the gene leads to a rare congenital immune deficiency called, chronic granulomatous disease (CGD). Deletion of NCF1 gene, which is a vital component of NADPH oxidase complex implicated in generation of oxidative stress, leads to Williams syndrome. It also act as a modifier of vascular stiffness.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.