General description
Retinoblastoma (Rb) is a pediatric intraocular neoplasm caused due to the biallelic inactivation of the RB1 gene. Retinoblastoma is also known as RB1 (RB transcriptional corepressor 1). It is located on human chromosome 13q14. It is a tumor suppressor gene.
Immunogen
synthetic phosphopeptide derived from the region of human Rb that contains Ser811.
Biochem/physiol Actions
Retinoblastoma (RB) interacts with several protein factors to control the expression of target genes which promote cell cycle arrest, apoptosis, and differentiation. It helps to modulate nucleosome and chromatin structures. Absence of RB induces prostate cancer metastasis.
Physical form
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
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- UPC:
- 51112023
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- R4278-1VL
- Temperature Control Device:
- Yes
