General description

The serum and glucocorticoid-regulated kinase (Sgk1) is a member of the AGC kinase family. It is located on human chromosome 6q23. Sgk1 is an aldosterone-induced protein kinase.

Immunogen

The antiserum was produced against synthesized peptide derived from human SGK around the phosphorylation site of Ser78.

Immunogen Range: 41-90

Biochem/physiol Actions

The serum- and glucocorticoid-regulated kinase (Sgk1) controls ENaC (expressed renal epithelial Na⁺ channel) by mineralocorticoids. SGK1 controls p27 phosphorylation upon the activation by mTOR-Raptor. This gene is essential to control blood pressure and hypertension in man.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.