ANTI-PHOSPHO-TAU (P-SER199/202) DEVELOPED IN RABBIT AFFINITY ISOLATED ANTIBODY

General description

Tau (τ), also known as MAPT (microtubule associated protein tau), is encoded by the gene mapped to human chromosome 17q21.3. It is highly expressed in neurons, but is most prominent in axons.

Tau proteins are known as microtubule-associated phosphoprotein (MAP) and express mainly in neurons of central nervous system. It has a crucial role in tubulin polymerization and facilitates microtubules assembly and stability. The biological activity of tau proteins depends on degree of its phosphorylation. Anti-phospho-Tau (pSer^199/202) antibody can be used in microarray and western blotting. It can also be used in immunoblotting. Rabbit anti- phospho-Tau (pSer^199/202) antibody reacts specifically with human Tau (pSer^199/202) (45-68 kD).

Immunogen

chemically synthesized phosphopeptide derived from the region of human tau that contains serine¹⁹⁹ and serine²⁰².

Application

Anti-phospho-Tau (pSer199/202) antibody produced in rabbit has been used in:

• immunocytochemistry
• immunohistochemistry
• western blot

Anti-phospho-Tau (pSer^199/202) antibody (diluted 1:1000 in PBS containing 0.3% Triton X-100 and 0.5% BSA) can be used in immunocytochemistry for identification of protein aggregates. It can also be used as primary antibody (diluted 1: 3000) in immunohistochemistry.

Biochem/physiol Actions

Tau (τ) plays an essential role in the assembly and maintenance of microtubule structure. Deletion of tau (τ) results in developmental delay and learning disability. The gene expression is associated with the development of Alzheimer′s disease (AD). Genetic variation in τ gene increases the risk of susceptibility to the sporadic tauopathies, progressive supranuclear palsy (PSP) and corticobasal degeneration.

Physical form

Solution in 100 μl Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, 50% glycerol, containing 1.0 mg/ml BSA (IgG, protease free) and 0.05% sodium azide. The amount of antibody is sufficient for 10 immunoblots.

Disclaimer

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