Immunogen
Peptide sequence around phosphorylation site of threonine 18 (Q-E-T(p)-F-S), according to the protein TP53.
Features and Benefits
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Target description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
- UPC:
- 12352203
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- SAB4300074-100UG
- Product Size:
- 100/µG
