ANTI-PHOX2A ANTIBODY (C005B-241431)

General description

Paired mesoderm homeobox protein 2A (PHOX2A), also known as ARIX1 homeodomain protein (ARIX) and Paired-like homeobox 2A (PMX2A), along with the closely related PHOX2B, is a paired-homeodomain transcription factor that maintains the noradrenergic phenotype during embryogenesis. PHOX2 proteins help regulate endogenous hydroxylases in neural crest cells and aid in sympathetic neuron generation. PHOX2A controls only the differentiation of the main noradrenergic center of the human brain, while PHOX2B is required for the differentiation of all central and nonperipheral noradrenergic centers. PHOX2A may be involved in regulating specific expression of catecholamine biosynthetic genes. PHOX2A is linked to congenital fibrosis of extraocular muscles type 2 (CFEOM2). PHOX2 regulation may have therapeutic applications for aging or degenerative noradrenergic neuron disorders.

Immunogen

KLH-conjugated linear peptide corresponding to human PHOX2A.

Application

Anti-PHOX2A Antibody is a highly specific rabbit polyclonal antibody, that targets Phox2a & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected PHOX2A in human brain tissue.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Quality

Evaluated by Western Blotting/Peptide Inhibition Assay in rat brain tissue lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1µg/mL of this antibody detected PHOX2A in 15 µg of rat brain tissue lysate.

Target description

~32 kDa observed. Uncharacterized bands may appear in some lysate(s).

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rat brain tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human, rat. technique(s): immunohistochemistry: suitable, western blot: suitable. UniProt accession no.: O14813. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... PHOX2A(401). Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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