ANTI-PKC ? ANTIBODY PRODUCED IN RABBIT (C15-1736-407)

General description

Protein kinase C (PKC) ϲ is an isoenzyme, which belongs to the atypical class of protein kinase C family. PKCϲ is encoded by the gene mapped to human chromosome 1p36.33-p36.2. PKC ϲ is expressed in human eosinophils. This protein is characterized with a PB1 (Phox and Bem1) domain in the N-terminal, a pseudosubstrate (PS) sequence, a C1 domain (or phorbol esters/diacylglycerol binding domain) of a single Cys-rich zinc-finger motif, and a kinase domain in the C-terminal.

Immunogen

The antiserum was produced against synthesized peptide derived from human PKC zeta.

Immunogen Range: 526-575

Application

Anti-PKC ϲ, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.

Biochem/physiol Actions

Isoenzymes of protein kinase C (PKC) family play a vital role in downstream signaling and cell functions. PKC ϲ regulates adhesion and effector functions of human eosinophils stimulated with platelet-activating factor (PAF) or complement (C) 5a. PKC ϲ and PKC δ might act as a therapeutic target for decreasing eosinophilic inflammation in clinical conditions such as asthma. PKC ϲ is calcium–independent, and is activated by phospholipids including phosphatidic acid (PA), phosphatidylinositol triphosphates and ceramides. Experimental studies state that, PKC ϲ is involved in the mitogen-activated protein kinase (MAPK) cascade, transcriptional factor NF-κB (NF-κB) activation, ribosomal S6-protein kinase signaling, and cell polarity. PKC-ϲ mediates hypoxia-induced Na,K-ATPase endocytosis in the alveolar epithelial cells (AEC).4 PKC-ϲ functions as a potential biomarker for human prostate cancer.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.