ANTI-PMP22 ANTIBODY PRODUCED IN RABBIT AFFINITY ISOLATED ANTIBODY ANTI-PMP22 ANTIBODY PRODUCED IN RABBIT AFFINITY ISOLATED ANTIB (C15-1876-437)

General description

PMP22 (peripheral myelin protein-22) is a tetraspan integral membrane protein, that contains four putative transmembrane domains. It is expressed in the peripheral nervous system. PMP22 is produced by myelinating Schwann cells. It is an important constituent of peripheral myelin. This gene is mapped to human chromosome 17p11.2.

Specificity

Anti-PMP22 recognizes human PMP22.

Immunogen

synthetic peptide corresponding to amino acid residues 118-133 of human PMP22, with an added cysteine, conjugated to KLH. The corresponding sequence differs by 3 amino acids in rat and mouse.

Biochem/physiol Actions

PMP22 (peripheral myelin protein-22) participates in the progression of CNS (central nervous system) myelin. It modulates self-renewal and chemoresistance of gastric cancer cells. Mutation in PMP22 results in Charcot-Marie tooth disease.

PMP22 plays a role in peripheral nerve myelin formation, cell-cell interactions, and cell proliferation. Overexpression of PMP22 is implicated in the neoplastic transformation of normal tissue to pre-malignant lesions and cancer of the pancreas and osteoblasts.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Legal Information

BiotinTag is a trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.