ANTI-POTASSIUM CHANNEL KV10.1 (EAG-1) PRODUCED IN RABBIT AFFINITY ISOLATED ANTIBODY (C005B-440611)

General description

Human genome codes for 40 voltage-gated K⁺ channels (K_V). Voltage-gated-like ion channels (VGICs) are the third largest group of signaling molecules found in humans. K⁺ channels can be divided into four structural types based on their number of transmembrane regions and mode of activation, namely K_ir- the inwardly rectifying 2-transmembrane K⁺ channels, K_2P- 2-pore 4-transmembrane K⁺ channels, K_Ca- Ca²⁺-activated 6-transmembrane or 7-transmembrane K⁺ channels, and K_V- voltage-gated 6-transmembrane K⁺ channels. KCNH1 (potassium voltage-gated channel H1) is a K_V channel and is also known as K_V10.1. Like all K_V members, it is composed of four α-subunits with each containing six transmembrane α-helical segments, and a membrane-re-entering P-loop. These surround a central pore as homotetramers or heterotetramers. KCNH1 mRNA and protein are both abundantly found in the brain, though its peripheral tissue expression is restricted. This gene is localized to human chromosome 1q32.1.

Specificity

Specific for K_V10.1 and does not cross react with K_V10.2.

Immunogen

peptide GDPAKRKGWARFKDAC corresponding to residues 802-817 of rat K_V10.1. This sequence is identical in mouse and has 14/16 residues identical in human.

Biochem/physiol Actions

KCNH1 (potassium voltage-gated channel H1) initiates a slowly activating, non-inactivating K₊ current in a heterologous system. In skeletal muscles, it is expressed only during the phase when myoblasts exit the cell cycle and fuse, and thus, it plays an essential role in skeletal muscle development. This protein is found to be expressed in ∼70% human cancers, including gastric, mammary tumors, colon carcinoma, and sarcomas. This channel is implicated in neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes.

Target description

Potassium Channel K_v10.1 (EAG-1) encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming α-subunit of a voltage-gated non-inactivating delayed rectifier potassium channel.

Physical form

Lyophilized from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

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