ANTI-PRAF2 (JM4) ANTIBODY (C005B-240611)

General description

Prenylated Rab acceptor 1 family protein 2 (PRAF2), or JM4, is a novel 19-kDa transmembrane protein belonging to the PRA1 family. It is highly expressed in the brain, and has been shown to be enriched in synaptic vesicles. PRAF2 is also relatively abundant in the spleen, small intestine, lung, pancreas, as well as various tumors affecting the ovary, breast, and colon. Recent studies have identified PRAF2 as a potential marker for neuroblastoma. Like other PRAF1 proteins, it is localized to the golgi, endoplasmic reticulum, and vesicular structures. The precise role of PRAF2 is not yet clear, but studies suggest that it may play a role in cellular transport processes.

Immunogen

KLH-conjugated linear peptide corresponding to human Praf2 (JM4).

Application

Anti-Praf2 (JM4) Antibody is an antibody against Praf2 (JM4) for use in Western Blotting & IHC.

Immunohistochemistry Analysis: A representative lot detected Praf2 (JM4) in mouse and human cerebellum tissue and in human breast cancer tissue.

Research Category
Apoptosis & Cancer

Neuroscience

Research Sub Category
Apoptosis - Additional

Synapse & Synaptic Biology

Quality

Western Blot Analysis: A 1:2,000 dilution from a representative lot detected Praf2 (JM4) in 10 µg of SK-N-SH cell lysate.

Target description

~18 kDa observed

Physical form

Rabbit polyclonal serum containing with 0.05% sodium azide.

Unpurified

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Analysis Note

Control
SK-N-SH cell lysate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: serum. antibody product type: primary antibodies. clone: polyclonal. species reactivity: mouse, human, rat. species reactivity (predicted by homology): bovine (based on 100% sequence homology), dog (based on 100% sequence homology), hamster (based on 100% sequence homology), guinea pig (based on 100% sequence homology), horse (based on 100% sequence homology). technique(s): immunohistochemistry: suitable, western blot: suitable. NCBI accession no.: NP_009144. UniProt accession no.: O60831. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... PRAF2(11230). Storage Class Code: 10 - Combustible liquids. WGK: WGK 1.

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