General description
PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis
Specificity
Other species have not been tested.
The antibody reacts with the 21 kDa Puma BH3 domain protein.
Immunogen
This antibody was developed against a synthetic peptide selected from the C-terminal region of human Puma.
Application
Anti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB.
Quality
Western Blot Analysis: 1:250 dilution of this antibody detected Puma BH3 domain on mouse brain lysate.
Target description
21 kDa
Physical form
Format: Purified
Analysis Note
Control
Western Blot : Mouse brain lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
biological source: rabbit. Quality Level: 100. antibody form: purified antibody. antibody product type: primary antibodies. clone: polyclonal. species reactivity: mouse. technique(s): western blot: suitable. NCBI accession no.: NP_055232. UniProt accession no.: Q9BXH1. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: mouse ... Bbc3(170770). Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 12352203
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- AB10418
