Anti-Resistin (C15-1316-062)

General description

Resistin (UniProt: Q9HD89; also known as Adipose tissue-specific secretory factor, ADSF,C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine-rich secreted protein FIZZ3) is encoded by the RETN (also known as FIZZ3, HXCP1, RSTN) gene (Gene ID: 56729) in rat. Resistin is a dilsulfide-linked homodimeric hormone secreted by the white adipose tissue. It is widely expressed, with strong expression in lung, bone marrow, and breast tissue. Resistin (resistance to insulin) was originally named for its ability to resist or interfere with the action of insulin. It has been linked to the development of atherosclerosis and cardiovascular diseases, non-alcoholic fatty liver disease, rheumatic disease, malignancy, asthma, inflammatory bowel disease and chronic kidney disease. It suppresses the ability of insulin to stimulate glucose uptake into adipose cells and is a key molecule linking obesity to diabetes. Circulating resistin levels are shown to be elevated in diet-induced and genetic forms of obesity and administration of anti-resistin antibody is shown to improve blood glucose levels and insulin action in mice with diet-induced obesity. Two isoforms of resistin have been described that are generated by alternative splicing. (Ref.: Jamaluddin MS et al (2012). Br J Pharmacol. 165(3); 622-632; Steppan, CM et al. (2001). Nature 409 (6818); 307-312).

Specificity

This rabbit polyclonal antibody detects Resistin in rat tissues. It targets an epitope within 17 amino acids from the N-terminal region.

Immunogen

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to 17 amino acids from the N-terminal region of rat resistin.

Application

Anti-Resistin Antibody, Cat. No. AB3371-I, is a rabbit polyclonal antibody that detects rat resistin and has been tested for use in Western Blotting.

Research Category
Inflammation & Immunology

Quality

Evaluated by Western Blotting in Resistin Recombinant Protein.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected recombinant rat resistin.

Target description

~12 kDa observed; 11.42 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Physical form

Affinity Purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: rat. packaging: antibody small pack of 25 . μ. L. technique(s): western blot: suitable. NCBI accession no.: NP_001180303.1. UniProt accession no.: Q9HD89. shipped in: ambient. target post-translational modification: unmodified. Gene Information: rat ... Retn(246250). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.