ANTI-RIBOSOMAL PROTEIN L26 (N-TERMINAL) ANTIBODY PRODUCED IN RABBIT AFFINITY ISOLATED ANTIBODY

General description

RPL26 (ribosomal protein L26) is located on chromosome 17. It codes for a 145-amino-acid long protein and has four exons. It is present on the large ribosomal subunit.

Ribosomal protein L26 is one of the large ribosomal subunit proteins.

Specificity

Anti-Ribosomal Protein L26 (N-terminal) specificallyrecognizes human Ribosomal Protein L26.

Immunogen

synthetic peptide corresponding to amino acids 1-17 of human ribosomal protein L26, conjugated to KLH via a C-terminal added cysteine residue. The sequence is conserved in human, rat, and mouse.

Application

Anti-Ribosomal Protein L26 (N-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunostaining
• immunofluorescence
• coimmunoprecipitation analysis

Biochem/physiol Actions

RPL26 (ribosomal protein L26) regulates the expression of p73. It plays an important role in translation and stability of ribosomes. RPL26 frameshift mutation can cause several physical abnormalities.

Ribosomal proteins are implicated in mRNA recognition, tRNA recognition and decoding and nuclear export. It was shown together with nucleolin to bind to the 5′ untranslated region of p53 mRNA and to control p53 translation and induction after DNA damage.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

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