General description
RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) is a nuclear serine/threonine protein kinase , that is located on human chromosome 14q32. It is a dual kinase domain protein.
Immunogen
Peptide sequence around aa. 374-378 (G-Y-S-F-V), according to the protein RPS6KA5.
Biochem/physiol Actions
RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) acts as a connector between extracellular signals and gene expression. It helps in the phosphorylation of chromatin protein histone H3 and high mobility group 14 (HMG14) . MSK1 plays a key role in the development of hormone-dependent breast cancer.
Features and Benefits
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Target description
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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- UPC:
- 51183702
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SAB4300458-100UG
- Temperature Control Device:
- Yes
