ANTI-SARCOLIPIN ANTIBODY (C005B-241770)

General description

Sarcolipin (SLN) is a multidomain protein containing lumenal, cytoplasmic, and transmembrane domains. It is found in the membrane of the sarcoplasmic/endoplasmic reticulum of cardiac cells, and is involved in maintaining calcium homestasis underlying muscle contractility in the heart. Sarcoplipin achieves these effects through its regulation of the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a), a calcium transport protein that actively pumps calcium from the cytoplasm into the sarcoplasmic reticulum, resulting in relaxation of the heart muscles. Sarcolipin may also interact with phospholamban, and may contribute to heart failure.

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of human Sarcolipin.

Application

Detect Sarcolipin using this Anti-Sarcolipin Antibody validated for use in Western Blotting.

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

Quality

Evaluated by Western Blot in rabbit quadraceps tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Sacolipin in rabbit quadraceps tissue lysate.

Target description

~6 kDa observed. An uncharacterized band may be observed at ~13 kDa in some tissue lysates.

Physical form

Affinity purified

Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rabbit quadraceps tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: rabbit. species reactivity (predicted by homology): rat (based on 100% sequence homology), human (immunogen homology), mouse (based on 100% sequence homology). technique(s): western blot: suitable. NCBI accession no.: NP_003054. UniProt accession no.: O00631. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... SLN(6588). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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